Mohapatra S.S.Wilson Z.E.Roy S.Ley S.V.2025-02-1720177http://dx.doi.org/10.1016/j.tet.2017.02.026https://idr.iitbbs.ac.in/handle/2008/1572Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation. � 2017 The AuthorsenAlkylationBis(indolyl)methanesCatalysisFlowScandium triflateArticle