A silica-gel accelerated [4?+?2] cycloaddition-based biomimetic approach towards the first total synthesis of magterpenoid C
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Date
2019
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Abstract
The first total synthesis of magterpenoid C has been realized via a silica gel accelerated biomimetic Diels-Alder reaction between ?-myrcene and randaiol derived quinone. However, application of similar strategy towards magterpenoid B via a protective Diels-Alder reaction failed to deliver the natural product. � 2019 Elsevier Ltd
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Keywords
Diels-Alder reaction, Meroterpenoids, Oxidative aromatization, Total synthesis, Traditional Chinese medicine (TCM)