Superparamagnetic iron oxide nanoparticle-based drug delivery in cancer therapeutics

Abstract

Recently, enormous progress has been achieved in the development of nanomaterials for their usage as effective anticancer drug delivery systems (DDs). Among different DDs, magnetic DDs (MDDs-i.e. magnetic nanoparticle-based DDs) have attained a great potential for clinical applications since they have the ability to improve the drug loading and delivery effectively via magnetic targeting apart from passive/active targeting methods. Herein, the loading of the drugs in these MDDs can be performed either (i) by attaching the drugs on the surface of the magnetic nanoparticles (MNPs) or (ii) by co-encapsulating the drugs along with MNPs inside the common drug delivery vehicles. Then, the drug delivery via MNPs can be performed by using intravenous administration followed by the stimuli-responsive controlled drug release in a site-specific manner inside the tumors by applying the magnetic field to induce chemotherapy/thermo-chemotherapy. In this book chapter, we discuss the as-developed MDDs including surface-modified MNPs, and MNPs/anticancer drug co-encapsulating nanomaterials including polymeric nanoparticles/micelles, niosomes, liposomes, and other magnetic structures. Then, we review in detail the delivery of different single/dual chemotherapeutic drug(s) via these MDDs in in vitro/vivo conditions for cancer treatments through chemotherapy and/or magnetic fluid hyperthermia (MFH) therapy. � 2021 John Wiley & Sons Ltd.