Zn(OTf) 2-catalyzed 1,6-conjugate addition of benzoxazinones to p -quinone methides: Access to 3,3-diaryl-2-(2-oxo-2 h -1,4-benzoxazin-3-yl)propanoic acid esters
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Date
2021
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Abstract
An effective method for the synthesis of 3,3-diaryl-2-(2-oxo-2 H -1,4-benzoxazin-3-yl)propanoic acid esters is reported. A novel zinc triflate-catalyzed regioselective 1,6-conjugate addition of vinylogous carbamates to p -quinone methides for accessing the title compounds has been developed. This protocol furnished the hybrid compounds in good to excellent yields. The reaction is rapid and has a broad substrate scope. � 2021. Thieme. All rights reserved.
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1,6-addition; Benzoxazines; Diastereoselectivity; Para -quinone methides; Regioselectivity; Vinylogous carbamates
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3