Hypersensitive and selective biosensing based on microfiber interferometry and molecular imprinted nanoparticles

Abstract

The molecular imprinting techniques with interferometric platform are promising for next-generation optical sensors for online and remote biosensing and device applications. This technique has shown a tremendous potential to provide a highly specific detection of target analyte/molecule with artificial complementary scaffolds in the polymeric nanostructures relay with tunable aspect ratio, low cost synthesis procedure and applicability in harsh environment. To date, no molecular imprinted nanoparticles has been integrated with optical microwire platform in the literature. Here, we report the synthesis of a molecularly imprinted nanocarrier using hydrothermal process that act as receptors and combines optical microwire as transducing support. The detailed sensing process for one of the widely used pesticides (parathion methyl) in the detection range of 10?12 to 10?4 M with hyper-sensitivity and detection limit of 1.30 � 1012 nm/M and 79.43 fM respectively have been achieved. The compact sensing probe tested with real water samples collected from various sources show percentage recovery of around 100%. We strongly believe that the process for probe development will open a new gateway for next generation selective biosensing for biomedical research applications. � 2019 Elsevier B.V.