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dc.contributor.authorDash S.P.en_US
dc.contributor.authorPanda A.K.en_US
dc.contributor.authorPasayat S.en_US
dc.contributor.authorMajumder S.en_US
dc.contributor.authorBiswas A.en_US
dc.contributor.authorKaminsky W.en_US
dc.contributor.authorMukhopadhyay S.en_US
dc.contributor.authorBhutia S.K.en_US
dc.contributor.authorDinda R.en_US
dc.description.abstractThree dioxidovanadium(V) complexes [VO2L1-3] (1-3) [HL1 = 1-napthoyl hydrazone of 2-acetyl pyridine, HL2 = 2-furoyl hydrazone of 2-acetyl pyridine and H2L3 = isonicotinoyl hydrazone of 2-hydroxy benzaldehyde] have been reported. All the complexes were characterized by various spectroscopy (IR, UV-visible and NMR) and the molecular structures of 1 and 2 were characterized by single crystal X-ray diffraction technique. Structural report established five-coordinate geometries, distorted toward square pyramidal for each of 1 and 2, based on a tridentate -O,N,N coordinating anion and two oxido-O atoms. The experimental results show that the complexes interact with calf-thymus DNA (CT-DNA) possibly by a groove binding mode, with binding constants of ? 105 M- 1. All complexes show good photo-induced cleavage of pUC19 supercoiled plasmid DNA with complex 1 showing the highest photo-induced DNA cleavage activity of ? 68%. 1-3 also exhibit moderate binding affinity in the range of 103-104 M- 1 towards bovine serum albumin (BSA), while all the complexes show good photo-induced BSA cleavage activity. Moreover the antiproliferative activity of all these complexes was studied, which reveal all compounds are significantly cytotoxic towards the HeLa cell line. � 2014 Elsevier Inc.en_US
dc.subjectBSA activityen_US
dc.subjectDioxidovanadium(V) aroylhydrazone complexesen_US
dc.subjectDNA binding and photo-induced cleavageen_US
dc.subjectX-ray crystal structureen_US
dc.titleEvaluation of the cell cytotoxicity and DNA/BSA binding and cleavage activity of some dioxidovanadium(V) complexes containing aroylhydrazonesen_US
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