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dc.contributor.authorKumar V.en_US
dc.contributor.authorAwasthi A.en_US
dc.contributor.authorSalam A.en_US
dc.contributor.authorKhan T.en_US
dc.date.accessioned2020-01-16T05:55:00Z-
dc.date.available2020-01-16T05:55:00Z-
dc.date.issued2019-
dc.identifier.citation1en_US
dc.identifier.urihttp://dx.doi.org/10.1021/acs.joc.9b01521-
dc.identifier.urihttp://10.10.32.48:8080/jspui/handle/2008/2138-
dc.description.abstractShort and scalable total syntheses of lamellarin G trimethyl ether, lamellarin D trimethyl ether, lamellarin H, lamellarin ?, dihydrolamellarin ?, and lamellarin U have been realized in four to six linear steps with an overall yield of ?22%. Highlights of the synthesis include single-step access to the central 1,2,4-trisubstituted pyrrole core in a highly regioselective manner via a one-pot [3+2] cycloaddition/elimination/aromatization sequence-based domino process. Subsequent, palladium-mediated double C-H oxidative coupling in a single-pot operation provides access to the pentacyclic coumarin-fused pyrrolo-dihydroisoquinoline core present in lamellarins. � 2019 American Chemical Society.en_US
dc.language.isoenen_US
dc.titleScalable Total Syntheses of Some Natural and Unnatural Lamellarins: Application of a One-Pot Domino Process for Regioselective Access to the Central 1,2,4-Trisubstituted Pyrrole Coreen_US
dc.typeArticleen_US
Appears in Collections:Research Publications

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