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Please use this identifier to cite or link to this item: http://idr.iitbbs.ac.in/jspui/handle/2008/2138
Title: Scalable Total Syntheses of Some Natural and Unnatural Lamellarins: Application of a One-Pot Domino Process for Regioselective Access to the Central 1,2,4-Trisubstituted Pyrrole Core
Authors: Kumar V.
Awasthi A.
Salam A.
Khan T.
Issue Date: 2019
Citation: 1
Abstract: Short and scalable total syntheses of lamellarin G trimethyl ether, lamellarin D trimethyl ether, lamellarin H, lamellarin ?, dihydrolamellarin ?, and lamellarin U have been realized in four to six linear steps with an overall yield of ?22%. Highlights of the synthesis include single-step access to the central 1,2,4-trisubstituted pyrrole core in a highly regioselective manner via a one-pot [3+2] cycloaddition/elimination/aromatization sequence-based domino process. Subsequent, palladium-mediated double C-H oxidative coupling in a single-pot operation provides access to the pentacyclic coumarin-fused pyrrolo-dihydroisoquinoline core present in lamellarins. � 2019 American Chemical Society.
URI: http://dx.doi.org/10.1021/acs.joc.9b01521
http://10.10.32.48:8080/jspui/handle/2008/2138
Appears in Collections:Research Publications

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